You will amaze by this Largest Protein Discovered
Titin, also known as connectin, holds the title of the largest known protein in the human body
Titin is exceptionally large, with a length exceeding 1 micrometer and a molecular weight approx 3,000 to 3,700 kilodaltons
Titin acts as a molecular spring, providing passive elasticity to muscle fibers.
The gene encoding titin,
TTN
, is notable for having the largest number of exons (363) of any gene
The concept of titin dates back to 1954 when Reiji Natori proposed the existence of an elastic structure in muscle fibers.
Mutations in the titin gene have been linked to conditions such as dilated cardiomyopathy
titin is not only the largest protein known but also a vital component of muscle function
Important in the contraction of
striated muscle tissues
; connects the
Z disc
to the
M line
in the
sarcomere
.